A NEW INDOLE DERIVATIVE, LWX-473, OVERCOMES GLUCOCORTICOID RESISTANCE IN JURKAT CELLS BY ACTIVATING MEDIATORS OF APOPTOSIS

A New Indole Derivative, LWX-473, Overcomes Glucocorticoid Resistance in Jurkat Cells by Activating Mediators of Apoptosis

Background: Glucocorticoids (GCs) are commonly used as the primary chemotherapy for lymphoid malignancies, including acute lymphoblastic leukemia (ALL).However, the MIG Guns development of GC resistance limits their prolonged use.Methods: In this study, we investigated the potential of a newly synthesized indole derivative called LWX-473, in combin

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Five Reasons Why I Am Skeptical That Indirect or Unconscious Lie Detection Is Superior to Direct Deception Detection

The relative advantage of indirect and Bodysuit unconscious lie detection compared to direct detection is examined.Empirical evidence for the superiority of indirect and unconscious lie is unconvincing.Three empirical issues include comparisons of incommensurate outcomes, questionable results in control conditions, and evidence for improved perform

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